ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

mib1

Alias:

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

72C2-72C2

Physical Location:

15999651-16004911 on NT_037436.3, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 57534 Symbol (Name): MIB1 (mindbomb homolog 1 (Drosophila))

Ortholog Status:

The human GeneID 57534 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		mib1
P Value:		1.69E-02
Note:		Acute up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_140569.2	NP_648826.2	NT_037436.3 range: 15999651..16004911, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IDA (15760269)
GO:0045179	apical cortex	Cellular Component	IDA (15760269)
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0004842	ubiquitin-protein ligase activity	Molecular Function	NAS (15829515)
GO:0005515	protein binding	Molecular Function	IPI (15829515\|17006545)
GO:0008593	regulation of Notch signaling pathway	Biological Process	IMP (15760269\|15930117)
GO:0016567	protein ubiquitination	Biological Process	NAS (15829515)
GO:0045747	positive regulation of Notch signaling pathway	Biological Process	IMP (15829515)
GO:0045807	positive regulation of endocytosis	Biological Process	NAS
GO:0046331	lateral inhibition	Biological Process	IMP (16093323)
GO:0001745	compound eye morphogenesis	Biological Process	IMP (15829515)
GO:0008587	imaginal disc-derived wing margin morphogenesis	Biological Process	NAS
GO:0008104	protein localization	Biological Process	IMP (15829515)
GO:0007480	imaginal disc-derived leg morphogenesis	Biological Process	IMP (15829515)
GO:0007476	imaginal disc-derived wing morphogenesis	Biological Process	IMP (15829515)
GO:0007423	sensory organ development	Biological Process	IMP (15829515\|16093323)
GO:0007219	Notch signaling pathway	Biological Process	IMP (16093323)
GO:0006897	endocytosis	Biological Process	IMP (15760269)
GO:0048749	compound eye development	Biological Process	NAS