ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pros26

Alias:

CG4097|DTS-5|DTS5|Pros26-DTS|beta6_dm|l(3)73Ai|l(3)DTS-5|l(3)DTS5

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

73B1-73B1

Physical Location:

16602496-16603520 on NT_037436.3, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5689 Symbol (Name): PSMB1 (proteasome (prosome, macropain) subunit, beta type, 1)

Ortholog Status:

The human GeneID 5689 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Pros26
P Value:		5.09E-03
Note:		Acute up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_079391.2	NP_524115.1	NT_037436.3 range: 16602496..16603520, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000502	proteasome complex	Cellular Component	NAS
GO:0005839	proteasome core complex	Cellular Component	NAS
GO:0005839	proteasome core complex	Cellular Component	ISS
GO:0005839	proteasome core complex	Cellular Component	IEA
GO:0004298	threonine endopeptidase activity	Molecular Function	IEA
GO:0004175	endopeptidase activity	Molecular Function	NAS
GO:0004175	endopeptidase activity	Molecular Function	ISS
GO:0006510	ATP-dependent proteolysis	Biological Process	NAS
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	NAS