ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

TSG101

Alias:

CG9712|DmTSG101|dVps23|ept

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

73D1-73D1

Physical Location:

16835398-16837685 on NT_037436.3

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7251 Symbol (Name): TSG101 (tumor susceptibility gene 101)

Ortholog Status:

The human GeneID 7251 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		TSG101
P Value:		7.13E-03
Note:		Acute up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_079396.2	NP_524120.1	NT_037436.3 range: 16835398..16837685

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005515	protein binding	Molecular Function	IPI
GO:0019787	small conjugating protein ligase activity	Molecular Function	IEA
GO:0006512	ubiquitin cycle	Biological Process	IEA
GO:0015031	protein transport	Biological Process	IEA
GO:0035090	maintenance of apical/basal cell polarity	Biological Process	IMP (16256744)
GO:0045571	negative regulation of imaginal disc growth	Biological Process	IMP (16256744)
GO:0045926	negative regulation of growth	Biological Process	IMP
GO:0046425	regulation of JAK-STAT cascade	Biological Process	IMP
GO:0051246	regulation of protein metabolic process	Biological Process	IEA