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Gene Information
Gene ID:39917
Organism:Drosophila melanogaster (Fly)
Genetic Location:73E5-73E5
Physical Location:17042615-17048555 on NT_037436.3
Gene Type:protein-coding
Human Ortholog:GeneID: 79641    Symbol (Name): ROGDI (rogdi homolog (Drosophila))
Ortholog Status:The human GeneID 79641 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:rogdi
P Value:1.74E-02
Note:Slow down-regulation, have human and mouse orthologs.
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_140699.2NP_648956.1NT_037436.3 range: 17042615..17048555
NM_168717.1NP_730244.1NT_037436.3 range: 17042615..17048555
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005575cellular_componentCellular ComponentND
GO:0003674molecular_functionMolecular FunctionND
GO:0007611learning and/or memoryBiological ProcessIMP (12593794)
GO:0008355olfactory learningBiological ProcessIMP (12593794)
Other Database Cross Links
NCBI Entrez Gene:39917