ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Mip

Alias:

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

74A5-74A5

Physical Location:

17338046-17342761 on NT_037436.3, complement

Gene Type:

protein-coding

Human Ortholog:

This gene has no human ortholog.

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_140714.3	NP_648971.1	NT_037436.3 range: 17338046..17342761, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005575	cellular_component	Cellular Component	ND
GO:0005179	hormone activity	Molecular Function	IDA (11181081)
GO:0016085	myoinhibitory hormone activity	Molecular Function	NAS
GO:0016087	ecdysiostatic hormone activity	Molecular Function	NAS
GO:0005184	neuropeptide hormone activity	Molecular Function	NAS (11179818\|11381038)
GO:0005179	hormone activity	Molecular Function	TAS (12171930)
GO:0005179	hormone activity	Molecular Function	NAS
GO:0007218	neuropeptide signaling pathway	Biological Process	NAS (11179818)
GO:0007218	neuropeptide signaling pathway	Biological Process	TAS (12171930)
GO:0007218	neuropeptide signaling pathway	Biological Process	IDA (11181081)