ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

ACCN1

Full Name:

amiloride-sensitive cation channel 1, neuronal (degenerin)

Alias:

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

17q12

Physical Location:

28364217-29507937 on NC_000017.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 11418 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D17S798

28313925

Region:		26313925-30313925
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005624	membrane fraction	Cellular Component	NR
GO:0005886	plasma membrane	Cellular Component	IEA
GO:0005887	integral to plasma membrane	Cellular Component	TAS (8626462)
GO:0005216	ion channel activity	Molecular Function	IEA
GO:0015280	amiloride-sensitive sodium channel activity	Molecular Function	TAS (8626462)
GO:0031402	sodium ion binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (11802773)
GO:0006811	ion transport	Biological Process	IEA
GO:0007268	synaptic transmission	Biological Process	TAS (8626462)
GO:0007417	central nervous system development	Biological Process	TAS (8626462)
GO:0007422	peripheral nervous system development	Biological Process	TAS (8626462)
GO:0006814	sodium ion transport	Biological Process	IEA