ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

40090

Symbol:

fz2

Alias:

CG9739|D-Fz2|DFZ2|DFz-2|Dfrz2|Dfz[[2]]|dfz(2)|dfz2r|fz-2

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

75F9-76A1

Physical Location:

19135997-19163725 on NT_037436.3, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 8325 Symbol (Name): FZD8 (frizzled homolog 8 (Drosophila))

Ortholog Status:

The human GeneID 8325 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		fz2
P Value:		4.01E-03
Note:		Slow up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001104173.1	NP_001097643.1	NT_037436.3 range: 19135997..19163725, complement
NM_079431.2	NP_524155.1	NT_037436.3 range: 19135997..19163725, complement
NM_168787.1	NP_730389.1	NT_037436.3 range: 19135997..19163725, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	ISS (10908591)
GO:0016021	integral to membrane	Cellular Component	NAS (8717036)
GO:0005886	plasma membrane	Cellular Component	NAS
GO:0005886	plasma membrane	Cellular Component	IDA (16530179)
GO:0005770	late endosome	Cellular Component	IDA (16530179)
GO:0005769	early endosome	Cellular Component	IDA (16530179)
GO:0004926	non-G-protein coupled 7TM receptor activity	Molecular Function	IEA
GO:0017147	Wnt-protein binding	Molecular Function	IDA (8717036)
GO:0042813	Wnt receptor activity	Molecular Function	IDA (8717036\|16530179)
GO:0042813	Wnt receptor activity	Molecular Function	NAS
GO:0004930	G-protein coupled receptor activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IDA (16291792)
GO:0004888	transmembrane receptor activity	Molecular Function	ISS (10908591)
GO:0016055	Wnt receptor signaling pathway	Biological Process	NAS
GO:0016055	Wnt receptor signaling pathway	Biological Process	IDA (8717036)
GO:0008585	female gonad development	Biological Process	IMP (11970894)
GO:0008407	bristle morphogenesis	Biological Process	IMP (16163385)
GO:0007223	Wnt receptor signaling pathway, calcium modulating pathway	Biological Process	IDA (8717036)
GO:0007165	signal transduction	Biological Process	ISS (10908591)
GO:0007163	establishment and/or maintenance of cell polarity	Biological Process	ISS (8717036)
GO:0006928	cell motility	Biological Process	IMP (11970894)
GO:0006898	receptor-mediated endocytosis	Biological Process	IMP (16291792)
GO:0048675	axon extension	Biological Process	IMP (17032066)