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Gene Information
Gene ID:40090
Organism:Drosophila melanogaster (Fly)
Genetic Location:75F9-76A1
Physical Location:19135997-19163725 on NT_037436.3, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 8325    Symbol (Name): FZD8 (frizzled homolog 8 (Drosophila))
Ortholog Status:The human GeneID 8325 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:fz2
P Value:4.01E-03
Note:Slow up-regulation, have human and mouse orthologs.
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001104173.1NP_001097643.1NT_037436.3 range: 19135997..19163725, complement
NM_079431.2NP_524155.1NT_037436.3 range: 19135997..19163725, complement
NM_168787.1NP_730389.1NT_037436.3 range: 19135997..19163725, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016021integral to membraneCellular ComponentISS (10908591)
GO:0016021integral to membraneCellular ComponentNAS (8717036)
GO:0005886plasma membraneCellular ComponentNAS
GO:0005886plasma membraneCellular ComponentIDA (16530179)
GO:0005770late endosomeCellular ComponentIDA (16530179)
GO:0005769early endosomeCellular ComponentIDA (16530179)
GO:0004926non-G-protein coupled 7TM receptor activityMolecular FunctionIEA
GO:0017147Wnt-protein bindingMolecular FunctionIDA (8717036)
GO:0042813Wnt receptor activityMolecular FunctionIDA (8717036|16530179)
GO:0042813Wnt receptor activityMolecular FunctionNAS
GO:0004930G-protein coupled receptor activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIDA (16291792)
GO:0004888transmembrane receptor activityMolecular FunctionISS (10908591)
GO:0016055Wnt receptor signaling pathwayBiological ProcessNAS
GO:0016055Wnt receptor signaling pathwayBiological ProcessIDA (8717036)
GO:0008585female gonad developmentBiological ProcessIMP (11970894)
GO:0008407bristle morphogenesisBiological ProcessIMP (16163385)
GO:0007223Wnt receptor signaling pathway, calcium modulating pathwayBiological ProcessIDA (8717036)
GO:0007165signal transductionBiological ProcessISS (10908591)
GO:0007163establishment and/or maintenance of cell polarityBiological ProcessISS (8717036)
GO:0006928cell motilityBiological ProcessIMP (11970894)
GO:0006898receptor-mediated endocytosisBiological ProcessIMP (16291792)
GO:0048675axon extensionBiological ProcessIMP (17032066)
Other Database Cross Links
NCBI Entrez Gene:40090