| Gene Information |
| Gene ID: | | 40136 |
| Symbol: | | lush |
| Alias: | | 76a|76c|76c(LUSH)|CG8807|Obp76a |
| Organism: | | Drosophila melanogaster (Fly) |
| Chromosome: | | 3L |
| Genetic Location: | | 76B9-76B9 |
| Physical Location: | | 19597496-19599189 on NT_037436.3, complement |
| Gene Type: | | protein-coding |
| Human Ortholog: | | This gene has no human ortholog. |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | lush | | P Value: | | 3.98E-04 | | Note: | | Acute down-regulation |
| | Dataset Information | | Name: | | 17054780 | | Method: | | Microarray | | Phenotype: | | Ethanol response | | Publication: | | Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed | | Summary: | | We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005576 | extracellular region | Cellular Component | IDA (9755202|11238251) | |
| GO:0005549 | odorant binding | Molecular Function | IEA | |
| GO:0005549 | odorant binding | Molecular Function | NAS (11238251) | |
| GO:0005549 | odorant binding | Molecular Function | TAS (14505368) | |
| GO:0035276 | ethanol binding | Molecular Function | IDA (14759510) | |
| GO:0035275 | dibutyl phthalate binding | Molecular Function | IDA (14759510) | |
| GO:0035274 | diphenyl phthalate binding | Molecular Function | IDA (14759510) | |
| GO:0045471 | response to ethanol | Biological Process | IDA (14759510) | |
| GO:0042048 | olfactory behavior | Biological Process | IMP (9755202|11238251) | |
| GO:0019236 | response to pheromone | Biological Process | IMP (15664171) | |
| GO:0007608 | sensory perception of smell | Biological Process | NAS | |
| GO:0007608 | sensory perception of smell | Biological Process | IMP (9755202) | |
| GO:0006810 | transport | Biological Process | IEA | |
| GO:0045471 | response to ethanol | Biological Process | TAS (14505368) | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 40136 |
| FLYBASE: | | FBgn0020277 |
