ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pitslre

Alias:

CG4268|Gat|Gta|cdk11|group 3

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

77E6-77E6

Physical Location:

20764636-20770036 on NT_037436.3

Gene Type:

protein-coding

Human Ortholog:

GeneID: 984 Symbol (Name): CDC2L1 (cell division cycle 2-like 1 (PITSLRE proteins))

Ortholog Status:

The human GeneID 984 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Pitslre
P Value:		2.20E-02
Note:		Acute up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	NAS
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IEA
GO:0004674	protein serine/threonine kinase activity	Molecular Function	ISS (1378625\|8930898)
GO:0004674	protein serine/threonine kinase activity	Molecular Function	NAS (10908587)
GO:0005524	ATP binding	Molecular Function	IEA
GO:0008360	regulation of cell shape	Biological Process	IMP (14527345)
GO:0007155	cell adhesion	Biological Process	IMP (14527345)
GO:0007049	cell cycle	Biological Process	IMP (14527345)
GO:0006468	protein amino acid phosphorylation	Biological Process	NAS (10908587)
GO:0006468	protein amino acid phosphorylation	Biological Process	ISS (1378625\|8930898)
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0051726	regulation of cell cycle	Biological Process	NAS