ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

LTF

Full Name:

lactotransferrin

Alias:

GIG12|HLF2|LF

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

3p21.31

Physical Location:

46452499-46481398 on NC_000003.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 17002 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

M93150

Dataset Information

Name:		12065639
Method:		Microarray
Tissue:		Frontal and motor cortices
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Mayfield et al. J Neurochem. (2002) Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. PubMed
Summary:		We used cDNA microarrays to analyze expression of approximately 10 000 genes in the frontal and motor cortices of three groups of chronic alcoholic and matched control cases. Fluorescent intensity ratios of 1.4-fold or greater in either direction (representing the 99% confidence interval) were used to indicate differentially expressed genes.

Gene Information

Original ID1:

LTF

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002343.2	NP_002334.2	NC_000003.10 range: 46452499..46481398, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	NR
GO:0004252	serine-type endopeptidase activity	Molecular Function	TAS (9770539)
GO:0008233	peptidase activity	Molecular Function	IEA
GO:0008199	ferric iron binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0006959	humoral immune response	Biological Process	TAS (9770539)
GO:0006826	iron ion transport	Biological Process	IEA
GO:0006811	ion transport	Biological Process	IEA
GO:0042742	defense response to bacterium	Biological Process	IEA
GO:0006879	cellular iron ion homeostasis	Biological Process	IEA