ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Or83b

Alias:

83A.2|83b|A45|CG10609|DOR45

Organism:

Drosophila melanogaster (Fly)

Chromosome:

3R

Genetic Location:

83A2-83A2

Physical Location:

1232901-1238127 on NT_033777.2, complement

Gene Type:

protein-coding

Human Ortholog:

This gene has no human ortholog.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Or83b
P Value:		2.61E-03
Note:		Acute down-regulation

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001104217.1	NP_001097687.1	NT_033777.2 range: 1232901..1238127, complement
NM_079511.4	NP_524235.2	NT_033777.2 range: 1232901..1238127, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0030425	dendrite	Cellular Component	IDA (16402857)
GO:0016021	integral to membrane	Cellular Component	ISS
GO:0005886	plasma membrane	Cellular Component	IDA (16402857)
GO:0004984	olfactory receptor activity	Molecular Function	IDA (16402857)
GO:0042803	protein homodimerization activity	Molecular Function	IDA (16402857)
GO:0005549	odorant binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (16402857)
GO:0004984	olfactory receptor activity	Molecular Function	NAS
GO:0004984	olfactory receptor activity	Molecular Function	ISS
GO:0007608	sensory perception of smell	Biological Process	IEA
GO:0007608	sensory perception of smell	Biological Process	NAS (11481464)
GO:0007608	sensory perception of smell	Biological Process	TAS (12593988)
GO:0042048	olfactory behavior	Biological Process	IMP (15339651\|16332533)
GO:0007608	sensory perception of smell	Biological Process	ISS

Other Database Cross Links

NCBI Entrez Gene:

FLYBASE: