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Gene Information
Gene ID:408217
Full Name:ubiquitin specific peptidase 11
Organism:Rattus norvegicus (Rat)
Genetic Location:Xq12
Physical Location:12890514-12906685 on NC_005120.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 8237    Symbol (Name): USP11 (ubiquitin specific peptidase 11)
Ortholog Status:The human GeneID 8237 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Usp11
Fold Change:-1.24
P Value:0.006
Note:Differential expression between ethanol and water groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001008861.2NP_001008861.2NC_005120.2 range: 12890514..12906685, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentTAS (12084015)
GO:0004197cysteine-type endopeptidase activityMolecular FunctionTAS (12084015)
GO:0004221ubiquitin thiolesterase activityMolecular FunctionIEA
GO:0006511ubiquitin-dependent protein catabolic processBiological ProcessIEA
GO:0006511ubiquitin-dependent protein catabolic processBiological ProcessTAS (12084015)
GO:0006512ubiquitin cycleBiological ProcessIEA
GO:0006512ubiquitin cycleBiological ProcessTAS (12084015)
Other Database Cross Links
NCBI Entrez Gene:408217