ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Usp11

Full Name:

ubiquitin specific peptidase 11

Alias:

MGC105909|Uhx1

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

Xq12

Physical Location:

12890514-12906685 on NC_005120.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 8237 Symbol (Name): USP11 (ubiquitin specific peptidase 11)

Ortholog Status:

The human GeneID 8237 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Usp11
Fold Change:		-1.24
P Value:		0.006
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001008861.2	NP_001008861.2	NC_005120.2 range: 12890514..12906685, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	TAS (12084015)
GO:0004197	cysteine-type endopeptidase activity	Molecular Function	TAS (12084015)
GO:0004221	ubiquitin thiolesterase activity	Molecular Function	IEA
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	TAS (12084015)
GO:0006512	ubiquitin cycle	Biological Process	IEA
GO:0006512	ubiquitin cycle	Biological Process	TAS (12084015)