ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Scr

Alias:

BG:DS07876.2|CG1030|Msc|l(3)84Af

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

84A5-84A5

Physical Location:

2648841-2675885 on NT_033777.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3202 Symbol (Name): HOXA5 (homeobox A5)

Ortholog Status:

The human GeneID 3202 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Scr
P Value:		3.55E-02
Note:		Slow up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	ISS
GO:0005634	nucleus	Cellular Component	NAS
GO:0003700	transcription factor activity	Molecular Function	IEA
GO:0003704	specific RNA polymerase II transcription factor activity	Molecular Function	ISS
GO:0003704	specific RNA polymerase II transcription factor activity	Molecular Function	NAS
GO:0043565	sequence-specific DNA binding	Molecular Function	IEA
GO:0045498	sex comb development	Biological Process	IMP (16299391)
GO:0007548	sex differentiation	Biological Process	TAS (11494318)
GO:0007494	midgut development	Biological Process	TAS (10512197)
GO:0007432	salivary gland boundary specification	Biological Process	TAS (11598957\|12742168)
GO:0007432	salivary gland boundary specification	Biological Process	NAS (14624839)
GO:0007381	specification of segmental identity, labial segment	Biological Process	TAS (11090137)
GO:0007379	segment specification	Biological Process	NAS (11090137)
GO:0006357	regulation of transcription from RNA polymerase II promoter	Biological Process	ISS
GO:0045498	sex comb development	Biological Process	NAS (11090137)