| Gene Information |
| Gene ID: | | 40835 |
| Symbol: | | Antp |
| Alias: | | 3.4|ANT-C|ANT-P|ANTC|Ant|AntP1|BG:DS07700.1|CG1028|DMANTPE1|DRO15DC96Z|DmAntp|Hu|Ns|Scx|l(3)84Ba |
| Organism: | | Drosophila melanogaster (Fly) |
| Chromosome: | | 3R |
| Genetic Location: | | 84A6-84B2 |
| Physical Location: | | 2721974-2824949 on NT_033777.2, complement |
| Gene Type: | | protein-coding |
| Human Ortholog: | | GeneID: 3203 Symbol (Name): HOXA6 (homeobox A6) |
| Ortholog Status: | | The human GeneID 3203 is not in current human dataset. |
|
| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | Antp | | P Value: | | 4.72E-02 | | Note: | | Acute down-regulation |
| | Dataset Information | | Name: | | 17054780 | | Method: | | Microarray | | Phenotype: | | Ethanol response | | Publication: | | Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed | | Summary: | | We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests. |
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|
| Gene Refseq Sequence Annotation |
| mRNA | Protein | Reference assembly Genomic | |
| NM_206444.1 | NP_996166.1 | NT_033777.2 range: 2721974..2824949, complement | | NM_206445.1 | NP_996167.1 | NT_033777.2 range: 2721974..2824949, complement | | NM_206446.1 | NP_996168.1 | NT_033777.2 range: 2721974..2824949, complement | | NM_206447.1 | NP_996169.1 | NT_033777.2 range: 2721974..2824949, complement | | NM_206448.1 | NP_996170.1 | NT_033777.2 range: 2721974..2824949, complement | | NM_206449.1 | NP_996171.1 | NT_033777.2 range: 2721974..2824949, complement | | NM_206450.1 | NP_996172.1 | NT_033777.2 range: 2721974..2824949, complement | | NM_206451.1 | NP_996173.1 | NT_033777.2 range: 2721974..2824949, complement | | NM_206452.1 | NP_996174.1 | NT_033777.2 range: 2721974..2824949, complement | | NM_206453.1 | NP_996175.1 | NT_033777.2 range: 2721974..2824949, complement | | NM_206454.1 | NP_996176.1 | NT_033777.2 range: 2721974..2824949, complement |
|
| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005634 | nucleus | Cellular Component | IEA | |
| GO:0005634 | nucleus | Cellular Component | NAS | |
| GO:0003700 | transcription factor activity | Molecular Function | IEA | |
| GO:0003704 | specific RNA polymerase II transcription factor activity | Molecular Function | NAS | |
| GO:0043565 | sequence-specific DNA binding | Molecular Function | IEA | |
| GO:0007507 | heart development | Biological Process | IEP (12435360) | |
| GO:0007494 | midgut development | Biological Process | TAS (10512197) | |
| GO:0007383 | specification of segmental identity, antennal segment | Biological Process | IMP (16299391) | |
| GO:0007379 | segment specification | Biological Process | NAS | |
| GO:0006357 | regulation of transcription from RNA polymerase II promoter | Biological Process | NAS | |
| GO:0006355 | regulation of transcription, DNA-dependent | Biological Process | IEA | |
| GO:0048542 | lymph gland development | Biological Process | IMP (17361183) | |
|
| Other Database Cross Links |
| NCBI Entrez Gene: | | 40835 |
| FLYBASE: | | FBgn0000095 |
