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Gene Information
Gene ID:40940
Symbol:dsx
Alias:CG11094|Dmdsx|Hr|ix-62c
Organism:Drosophila melanogaster (Fly)
Chromosome:3R
Genetic Location:84E5-84E6
Physical Location:3750044-3793129 on NT_033777.2, complement
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:dsx
P Value:1.11E-02
Note:Slow down-regulation
Dataset Information
Name:17054780
Method:Microarray
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_079548.4NP_524272.4NT_033777.2 range: 3750044..3793129, complement
NM_169202.1NP_731197.1NT_033777.2 range: 3750044..3793129, complement
NM_169203.1NP_731198.1NT_033777.2 range: 3750044..3793129, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentISS
GO:0003702RNA polymerase II transcription factor activityMolecular FunctionTAS (11092827)
GO:0008270zinc ion bindingMolecular FunctionNAS
GO:0003729mRNA bindingMolecular FunctionNAS (12000098)
GO:0003704specific RNA polymerase II transcription factor activityMolecular FunctionNAS
GO:0003704specific RNA polymerase II transcription factor activityMolecular FunctionISS
GO:0030528transcription regulator activityMolecular FunctionTAS (12484523)
GO:0003700transcription factor activityMolecular FunctionNAS (10648226)
GO:0003700transcription factor activityMolecular FunctionIEA
GO:0003677DNA bindingMolecular FunctionTAS (12000098|12350340)
GO:0003677DNA bindingMolecular FunctionNAS
GO:0045449regulation of transcriptionBiological ProcessTAS (12484523)
GO:0045433male courtship behavior, veined wing generated song productionBiological ProcessTAS (11300999|12000098)
GO:0045433male courtship behavior, veined wing generated song productionBiological ProcessNAS (11092827|11715043)
GO:0035263genital disc sexually dimorphic developmentBiological ProcessTAS (11494318)
GO:0035215genital disc developmentBiological ProcessTAS (11494318)
GO:0035215genital disc developmentBiological ProcessIMP (11245569)
GO:0019102male somatic sex determinationBiological ProcessNAS (11300999)
GO:0045496male analia developmentBiological ProcessNAS (11494318)
GO:0045497female analia developmentBiological ProcessNAS (11494318)
GO:0045498sex comb developmentBiological ProcessTAS (11494318)
GO:0048086negative regulation of pigmentation during developmentBiological ProcessTAS (12350340)
GO:0048071sex-specific pigmentationBiological ProcessTAS (12957543)
GO:0048071sex-specific pigmentationBiological ProcessNAS (12459721)
GO:0046661male sex differentiationBiological ProcessTAS (12484523)
GO:0046660female sex differentiationBiological ProcessTAS (12484523)
GO:0045944positive regulation of transcription from RNA polymerase II promoterBiological ProcessTAS (12350340)
GO:0045893positive regulation of transcription, DNA-dependentBiological ProcessNAS (12508274)
GO:0045892negative regulation of transcription, DNA-dependentBiological ProcessNAS (12508274)
GO:0045570regulation of imaginal disc growthBiological ProcessTAS (12350340)
GO:0019101female somatic sex determinationBiological ProcessTAS (8970731)
GO:0019101female somatic sex determinationBiological ProcessNAS (11300999)
GO:0007485imaginal disc-derived male genitalia developmentBiological ProcessNAS (11494318)
GO:0007485imaginal disc-derived male genitalia developmentBiological ProcessIGI (11245569)
GO:0007483genital disc morphogenesisBiological ProcessTAS (12350340)
GO:0007417central nervous system developmentBiological ProcessTAS (12000098)
GO:0007283spermatogenesisBiological ProcessNAS (8970731)
GO:0006366transcription from RNA polymerase II promoterBiological ProcessNAS
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0000122negative regulation of transcription from RNA polymerase II promoterBiological ProcessTAS (12350340)
GO:0007486imaginal disc-derived female genitalia developmentBiological ProcessIGI (11245569)
GO:0007486imaginal disc-derived female genitalia developmentBiological ProcessNAS (11494318)
GO:0007530sex determinationBiological ProcessNAS (11092827)
GO:0018993somatic sex determinationBiological ProcessTAS (12350340)
GO:0018993somatic sex determinationBiological ProcessNAS (10648226)
GO:0008049male courtship behaviorBiological ProcessTAS (11300999)
GO:0007619courtship behaviorBiological ProcessNAS (11092827)
GO:0007610behaviorBiological ProcessTAS (12486700)
GO:0007548sex differentiationBiological ProcessTAS (12000098|12350340|12486700|12596226)
GO:0007548sex differentiationBiological ProcessNAS (10648226|11300999)
GO:0007530sex determinationBiological ProcessTAS (12484523|12486700|15382141)
GO:0000398nuclear mRNA splicing, via spliceosomeBiological ProcessTAS (12484523)
Other Database Cross Links
NCBI Entrez Gene:40940
FLYBASE:FBgn0000504