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Gene Information
Gene ID:40961
Symbol:CG7891
Organism:Drosophila melanogaster (Fly)
Chromosome:3R
Genetic Location:84E13-84E13
Physical Location:3952335-3954567 on NT_033777.2
Gene Type:protein-coding
Human Ortholog:GeneID: 55207    Symbol (Name): ARL8B (ADP-ribosylation factor-like 8B)
Ortholog Status:The human GeneID 55207 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:CG7891
P Value:2.59E-02
Note:Slow up-regulation, have human and mouse orthologs.
Dataset Information
Name:17054780
Method:Microarray
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_141512.2NP_649769.1NT_033777.2 range: 3952335..3954567
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005622intracellularCellular ComponentIEA
GO:0005525GTP bindingMolecular FunctionISS
GO:0007264small GTPase mediated signal transductionBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:40961
FLYBASE:FBgn0037551