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Gene Information
Gene ID:41032
Symbol:hb
Alias:CG9786|Hb|Hunchback|R-pbx|Rg-bx|Rg-pbx|hbHLH|l(3)85Ah
Organism:Drosophila melanogaster (Fly)
Chromosome:3R
Genetic Location:85A5-85A5
Physical Location:4517037-4523539 on NT_033777.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 64376    Symbol (Name): IKZF5 (IKAROS family zinc finger 5 (Pegasus))
Ortholog Status:The human GeneID 64376 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:hb
P Value:1.94E-02
Note:Slow up-regulation, have human and mouse orthologs.
Dataset Information
Name:17054780
Method:Microarray
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_169233.1NP_731267.1NT_033777.2 range: 4517037..4523539, complement
NM_169234.1NP_731268.1NT_033777.2 range: 4517037..4523539, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005622intracellularCellular ComponentIEA
GO:0005634nucleusCellular ComponentNAS
GO:0003677DNA bindingMolecular FunctionIDA (1671661)
GO:0003704specific RNA polymerase II transcription factor activityMolecular FunctionNAS
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0016563transcription activator activityMolecular FunctionIDA (1671661)
GO:0001763morphogenesis of a branching structureBiological ProcessTAS (11063940)
GO:0008293torso signaling pathwayBiological ProcessIGI (1905816)
GO:0008595determination of anterior/posterior axis, embryoBiological ProcessNAS (11700289)
GO:0035289posterior head segmentationBiological ProcessTAS (15382142)
GO:0035290trunk segmentationBiological ProcessTAS (15382142)
GO:0040034regulation of development, heterochronicBiological ProcessTAS (11835276|12142272|12809598|14588255)
GO:0042659regulation of cell fate specificationBiological ProcessTAS (12809598)
GO:0045449regulation of transcriptionBiological ProcessNAS (12809598)
GO:0007431salivary gland developmentBiological ProcessTAS (11598957)
GO:0007427epithelial cell migration, open tracheal systemBiological ProcessTAS (14570584)
GO:0007424open tracheal system developmentBiological ProcessTAS (11063940|11835274|12791296)
GO:0007354zygotic determination of anterior/posterior axis, embryoBiological ProcessNAS (11691830)
GO:0007354zygotic determination of anterior/posterior axis, embryoBiological ProcessTAS (15382142)
GO:0007355anterior region determinationBiological ProcessNAS (11845195)
GO:0007362terminal region determinationBiological ProcessIGI (1905816)
GO:0007400neuroblast fate determinationBiological ProcessIEP (11525736)
GO:0007400neuroblast fate determinationBiological ProcessIMP (11525736|11861485)
GO:0007402ganglion mother cell fate determinationBiological ProcessTAS (12593977)
GO:0007417central nervous system developmentBiological ProcessTAS (12809598)
GO:0007419ventral cord developmentBiological ProcessNAS (12593977)
GO:0045941positive regulation of transcriptionBiological ProcessIDA (1671661)
Other Database Cross Links
NCBI Entrez Gene:41032
FLYBASE:FBgn0001180