ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CG8129

Alias:

CT24308

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

85D12-85D13

Physical Location:

5191141-5193487 on NT_033777.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 63826 Symbol (Name): SRR (serine racemase)

Ortholog Status:

The human GeneID 63826 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0004794	L-threonine ammonia-lyase activity	Molecular Function	ISS
GO:0016597	amino acid binding	Molecular Function	IEA
GO:0030170	pyridoxal phosphate binding	Molecular Function	IEA
GO:0008152	metabolic process	Biological Process	IEA