ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Scm

Alias:

CG9495|Su(z)302|l(3)85Ef

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

85E2-85E2

Physical Location:

5459080-5463328 on NT_033777.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 22955 Symbol (Name): SCMH1 (sex comb on midleg homolog 1 (Drosophila))

Ortholog Status:

The human GeneID 22955 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_169299.1	NP_731385.1	NT_033777.2 range: 5459080..5463328, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (16618800)
GO:0005634	nucleus	Cellular Component	NAS
GO:0035102	PRC1 complex	Cellular Component	TAS (15337121)
GO:0003704	specific RNA polymerase II transcription factor activity	Molecular Function	NAS
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0045449	regulation of transcription	Biological Process	IEA
GO:0030713	ovarian follicle cell stalk formation	Biological Process	IMP (14993188)
GO:0030708	germarium-derived female germ-line cyst encapsulation	Biological Process	IMP (14993188)
GO:0022008	neurogenesis	Biological Process	IMP (17287254)
GO:0016458	gene silencing	Biological Process	IMP (11333237)
GO:0016458	gene silencing	Biological Process	IGI (11333237)
GO:0045449	regulation of transcription	Biological Process	NAS