ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

MAN2A2

Full Name:

mannosidase, alpha, class 2A, member 2

Alias:

MANA2X

Organism:

Homo sapiens (Human)

Chromosome:

15

Genetic Location:

15q26.1

Physical Location:

89248423-89266818 on NC_000015.8

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.116459
Note:		"Class II, down-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_006122.2	NP_006113.2	NC_000015.8 range: 89248423..89266818

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000139	Golgi membrane	Cellular Component	NAS
GO:0005794	Golgi apparatus	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0030246	carbohydrate binding	Molecular Function	IEA
GO:0016798	hydrolase activity, acting on glycosyl bonds	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0004572	mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity	Molecular Function	NAS
GO:0004559	alpha-mannosidase activity	Molecular Function	IEA
GO:0006013	mannose metabolic process	Biological Process	IEA
GO:0005975	carbohydrate metabolic process	Biological Process	NAS
GO:0008152	metabolic process	Biological Process	IEA

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000196547

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: