ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Sodh-2

Alias:

CG4649|DM_7299382|Sdh|Sdh-2

Organism:

Drosophila melanogaster (Fly)

Chromosome:

3R

Genetic Location:

86C7-86C7

Physical Location:

6702105-6703987 on NT_033777.2

Gene Type:

protein-coding

Human Ortholog:

This gene has no human ortholog.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Sodh-2
P Value:		3.02E-02
Note:		Acute down-regulation

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_079587.2	NP_524311.1	NT_033777.2 range: 6702105..6703987

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0003939	L-iditol 2-dehydrogenase activity	Molecular Function	ISS
GO:0003939	L-iditol 2-dehydrogenase activity	Molecular Function	TAS (1582561)
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0008152	metabolic process	Biological Process	IEA

Other Database Cross Links

NCBI Entrez Gene:

FLYBASE: