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Gene Information
Gene ID:41347
Symbol:RpL3
Alias:CG4863|anon-EST:GressD4
Organism:Drosophila melanogaster (Fly)
Chromosome:3R
Genetic Location:86D8-86D8
Physical Location:7047617-7050896 on NT_033777.2
Gene Type:protein-coding
Human Ortholog:GeneID: 6122    Symbol (Name): RPL3 (ribosomal protein L3)
Ortholog Status:The human GeneID 6122 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:RpL3
P Value:4.19E-03
Note:Acute up-regulation, have human and mouse orthologs.
Dataset Information
Name:17054780
Method:Microarray
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_079592.2NP_524316.1NT_033777.2 range: 7047617..7050896
NM_169377.1NP_731547.1NT_033777.2 range: 7047617..7050896
NM_169378.1NP_731548.1NT_033777.2 range: 7047617..7050896
NM_169379.1NP_731549.1NT_033777.2 range: 7047617..7050896
NM_169380.1NP_731550.1NT_033777.2 range: 7047617..7050896
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0022625cytosolic large ribosomal subunitCellular ComponentISS
GO:0022625cytosolic large ribosomal subunitCellular ComponentNAS
GO:0022626cytosolic ribosomeCellular ComponentNAS
GO:0003735structural constituent of ribosomeMolecular FunctionISS
GO:0003735structural constituent of ribosomeMolecular FunctionNAS
GO:0000022mitotic spindle elongationBiological ProcessIMP (17412918)
GO:0006412translationBiological ProcessISS
GO:0006412translationBiological ProcessNAS
GO:0007052mitotic spindle organization and biogenesisBiological ProcessIMP (17412918)
Other Database Cross Links
NCBI Entrez Gene:41347
FLYBASE:FBgn0020910