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Gene Information
Gene ID:41469
Symbol:CG14741
Organism:Drosophila melanogaster (Fly)
Chromosome:3R
Genetic Location:87A7-87A7
Physical Location:7895304-7903197 on NT_033777.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 57198    Symbol (Name): ATP8B2 (ATPase, class I, type 8B, member 2)
Ortholog Status:The human GeneID 57198 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:CG14741
P Value:4.70E-02
Note:Transient down-regulation, have human and mouse orthologs.
Dataset Information
Name:17054780
Method:Microarray
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_169450.1NP_731669.1NT_033777.2 range: 7895304..7903197, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016021integral to membraneCellular ComponentIEA
GO:0000287magnesium ion bindingMolecular FunctionIEA
GO:0004012phospholipid-translocating ATPase activityMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0015662ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanismMolecular FunctionISS
GO:0006812cation transportBiological ProcessIEA
GO:0008152metabolic processBiological ProcessIEA
GO:0015914phospholipid transportBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:41469
FLYBASE:FBgn0037989