| Gene Information |
| Gene ID: | | 41469 |
| Symbol: | | CG14741 |
| Organism: | | Drosophila melanogaster (Fly) |
| Chromosome: | | 3R |
| Genetic Location: | | 87A7-87A7 |
| Physical Location: | | 7895304-7903197 on NT_033777.2, complement |
| Gene Type: | | protein-coding |
| Human Ortholog: | | GeneID: 57198 Symbol (Name): ATP8B2 (ATPase, class I, type 8B, member 2) |
| Ortholog Status: | | The human GeneID 57198 is not in current human dataset. |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | CG14741 | | P Value: | | 4.70E-02 | | Note: | | Transient down-regulation, have human and mouse orthologs. |
| | Dataset Information | | Name: | | 17054780 | | Method: | | Microarray | | Phenotype: | | Ethanol response | | Publication: | | Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed | | Summary: | | We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0016021 | integral to membrane | Cellular Component | IEA | |
| GO:0000287 | magnesium ion binding | Molecular Function | IEA | |
| GO:0004012 | phospholipid-translocating ATPase activity | Molecular Function | IEA | |
| GO:0005524 | ATP binding | Molecular Function | IEA | |
| GO:0015662 | ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism | Molecular Function | ISS | |
| GO:0006812 | cation transport | Biological Process | IEA | |
| GO:0008152 | metabolic process | Biological Process | IEA | |
| GO:0015914 | phospholipid transport | Biological Process | IEA | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 41469 |
| FLYBASE: | | FBgn0037989 |
