ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Alias:

CG7642|XDH|XOR|Xdh/ry|unnamed

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

87D9-87D9

Physical Location:

8858258-8863747 on NT_033777.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7498 Symbol (Name): XDH (xanthine dehydrogenase)

Ortholog Status:

The human GeneID 7498 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		ry
P Value:		3.30E-02
Note:		Slow down-regulation, have human orthologs

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_079613.2	NP_524337.1	NT_033777.2 range: 8858258..8863747

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005777	peroxisome	Cellular Component	NAS
GO:0004854	xanthine dehydrogenase activity	Molecular Function	IEA
GO:0050660	FAD binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0009055	electron carrier activity	Molecular Function	IEA
GO:0051536	iron-sulfur cluster binding	Molecular Function	IEA
GO:0004855	xanthine oxidase activity	Molecular Function	IEA
GO:0004854	xanthine dehydrogenase activity	Molecular Function	TAS (1582561)
GO:0004854	xanthine dehydrogenase activity	Molecular Function	NAS
GO:0048072	compound eye pigmentation	Biological Process	TAS (1783294)
GO:0008340	determination of adult life span	Biological Process	IMP (17435236)