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Gene Information
Gene ID:41670
Symbol:B52
Alias:B52/SRp55|B52/dSRp55|CG10851|E(Dfd)|E726|MabB52|RRM8|RSp55|Rbp8|SR55|SRp55|dSRp55|l(3)s2249
Organism:Drosophila melanogaster (Fly)
Chromosome:3R
Genetic Location:87F7-87F7
Physical Location:9487021-9492616 on NT_033777.2
Gene Type:protein-coding
Human Ortholog:GeneID: 6429    Symbol (Name): SFRS4 (splicing factor, arginine/serine-rich 4)
Ortholog Status:The human GeneID 6429 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:B52
P Value:4.69E-02
Note:Slow up-regulation, have human and mouse orthologs.
Dataset Information
Name:17054780
Method:Microarray
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001014619.1NP_001014619.1NT_033777.2 range: 9487021..9492616
NM_176488.1NP_788665.1NT_033777.2 range: 9487021..9492616
NM_176489.1NP_788666.1NT_033777.2 range: 9487021..9492616
NM_176490.1NP_788667.1NT_033777.2 range: 9487021..9492616
NM_176491.1NP_788668.1NT_033777.2 range: 9487021..9492616
NM_176492.2NP_788669.1NT_033777.2 range: 9487021..9492616
NM_176493.2NP_788670.1NT_033777.2 range: 9487021..9492616
NM_176494.2NP_788671.1NT_033777.2 range: 9487021..9492616
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIC (15492211)
GO:0035062omega speckleCellular ComponentIDA (10984439)
GO:0016607nuclear speckCellular ComponentIDA (10984439)
GO:0005634nucleusCellular ComponentNAS
GO:0005634nucleusCellular ComponentIDA (1885003|12134081)
GO:0031202RNA splicing factor activity, transesterification mechanismMolecular FunctionISS (10908584)
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (12134081)
GO:0003729mRNA bindingMolecular FunctionNAS
GO:0003729mRNA bindingMolecular FunctionISS (10908586)
GO:0006376mRNA splice site selectionBiological ProcessISS (10908584)
GO:0000398nuclear mRNA splicing, via spliceosomeBiological ProcessNAS
GO:0000398nuclear mRNA splicing, via spliceosomeBiological ProcessIDA (10594020)
GO:0000381regulation of alternative nuclear mRNA splicing, via spliceosomeBiological ProcessIMP (15492211)
GO:0048024regulation of nuclear mRNA splicing, via spliceosomeBiological ProcessIMP (15937219)
Other Database Cross Links
NCBI Entrez Gene:41670
FLYBASE:FBgn0004587