ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

cher

Alias:

CG3937|FLN|sko

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

89E12-89E13

Physical Location:

12917256-12944862 on NT_033777.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2316 Symbol (Name): FLNA (filamin A, alpha (actin binding protein 280))

Ortholog Status:

The human GeneID 2316 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		cher
P Value:		1.71E-02
Note:		Slow up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0035183	germline ring canal inner rim	Cellular Component	IDA (10556087)
GO:0035182	germline ring canal outer rim	Cellular Component	IDA (10556087)
GO:0003779	actin binding	Molecular Function	ISS (10556087\|10908588)
GO:0030725	ring canal formation	Biological Process	IMP (12885568)
GO:0030708	germarium-derived female germ-line cyst encapsulation	Biological Process	IMP (12885568)
GO:0008355	olfactory learning	Biological Process	IMP (12593794)
GO:0008340	determination of adult life span	Biological Process	IMP (12620118)
GO:0008302	ring canal formation, actin assembly	Biological Process	IMP (10556087)
GO:0008104	protein localization	Biological Process	IMP (9093858)
GO:0007611	learning and/or memory	Biological Process	IMP (12593794)
GO:0007301	ovarian ring canal formation	Biological Process	IMP (9093858)
GO:0035204	negative regulation of lamellocyte differentiation	Biological Process	IMP (16616709)