| Gene Information |
| Gene ID: | | 42294 |
| Symbol: | | Cyp12a4 |
| Alias: | | 12a4|CG6042|P450 |
| Organism: | | Drosophila melanogaster (Fly) |
| Chromosome: | | 3R |
| Genetic Location: | | 91F3-91F3 |
| Physical Location: | | 14960880-14962861 on NT_033777.2 |
| Gene Type: | | protein-coding |
| Human Ortholog: | | This gene has no human ortholog. |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | Cyp12a4 | | P Value: | | 1.74E-02 | | Note: | | Transient up-regulation |
| | Dataset Information | | Name: | | 17054780 | | Method: | | Microarray | | Phenotype: | | Ethanol response | | Publication: | | Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed | | Summary: | | We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005739 | mitochondrion | Cellular Component | ISS | |
| GO:0005739 | mitochondrion | Cellular Component | NAS | |
| GO:0004497 | monooxygenase activity | Molecular Function | IEA | |
| GO:0005506 | iron ion binding | Molecular Function | IEA | |
| GO:0009055 | electron carrier activity | Molecular Function | ISS | |
| GO:0009055 | electron carrier activity | Molecular Function | NAS | |
| GO:0020037 | heme binding | Molecular Function | IEA | |
| GO:0017085 | response to insecticide | Biological Process | IMP (16120680) | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 42294 |
| FLYBASE: | | FBgn0038681 |
