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Gene Information
Gene ID:42294
Symbol:Cyp12a4
Alias:12a4|CG6042|P450
Organism:Drosophila melanogaster (Fly)
Chromosome:3R
Genetic Location:91F3-91F3
Physical Location:14960880-14962861 on NT_033777.2
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Cyp12a4
P Value:1.74E-02
Note:Transient up-regulation
Dataset Information
Name:17054780
Method:Microarray
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_142526.2NP_650783.2NT_033777.2 range: 14960880..14962861
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005739mitochondrionCellular ComponentISS
GO:0005739mitochondrionCellular ComponentNAS
GO:0004497monooxygenase activityMolecular FunctionIEA
GO:0005506iron ion bindingMolecular FunctionIEA
GO:0009055electron carrier activityMolecular FunctionISS
GO:0009055electron carrier activityMolecular FunctionNAS
GO:0020037heme bindingMolecular FunctionIEA
GO:0017085response to insecticideBiological ProcessIMP (16120680)
Other Database Cross Links
NCBI Entrez Gene:42294
FLYBASE:FBgn0038681