ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Hs6st

Alias:

CG11683|CG17188|CG18533|CG4451|DmHs6st|dHS6ST

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

92B9-92C1

Physical Location:

15755435-15834243 on NT_033777.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 9394 Symbol (Name): HS6ST1 (heparan sulfate 6-O-sulfotransferase 1)

Ortholog Status:

The human GeneID 9394 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs6st
P Value:		2.44E-02
Note:		Slow up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_079685.2	NP_524409.2	NT_033777.2 range: 15755435..15834243, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0017095	heparan sulfate 6-O-sulfotransferase activity	Molecular Function	NAS
GO:0007424	open tracheal system development	Biological Process	IGI (16966419)
GO:0007424	open tracheal system development	Biological Process	IMP (16966419)
GO:0007428	primary branching, open tracheal system	Biological Process	TAS (14570584)
GO:0008543	fibroblast growth factor receptor signaling pathway	Biological Process	TAS (14570584)
GO:0015012	heparan sulfate proteoglycan biosynthetic process	Biological Process	TAS (14570584)