ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CG17838

Alias:

AI945337|l(3)03806

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

92F12-93A1

Physical Location:

16582450-16631962 on NT_033777.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 10236 Symbol (Name): HNRNPR (heterogeneous nuclear ribonucleoprotein R)

Ortholog Status:

The human GeneID 10236 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		CG17838
P Value:		3.96E-02
Note:		Slow up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0030530	heterogeneous nuclear ribonucleoprotein complex	Cellular Component	ISS
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0003676	nucleic acid binding	Molecular Function	IEA
GO:0003729	mRNA binding	Molecular Function	ISS (10908586)