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Gene Information
Gene ID:4247
Symbol:MGAT2
Full Name:mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
Alias:CDGS2|GLCNACTII|GNT-II|GNT2
Organism:Homo sapiens (Human)
Chromosome:14
Genetic Location:14q21
Physical Location:49157238-49159948 on NC_000014.7
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Hs.93338
Note:"Class II, up-regulated gene"
Dataset Information
Name:16292326
Method:Microarray
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_002408.3NP_002399.1NC_000014.7 range: 49157238..49159948
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0000139Golgi membraneCellular ComponentIEA
GO:0005624membrane fractionCellular ComponentTAS (7797505)
GO:0005794Golgi apparatusCellular ComponentIEA
GO:0005795Golgi stackCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0008455alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activityMolecular FunctionTAS (7635144)
GO:0016757transferase activity, transferring glycosyl groupsMolecular FunctionIEA
GO:0009312oligosaccharide biosynthetic processBiological ProcessIEA
GO:0006487protein amino acid N-linked glycosylationBiological ProcessTAS (7635144)
Other Database Cross Links
NCBI Entrez Gene:4247
HGNC:7045
Ensembl:ENSG00000168282
MIM:602616
HPRD:04013
HuGE Navigator:4247
dbSNP:MGAT2
GeneCard:MGAT2
AceView:MGAT2