ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Mpk2

Alias:

CG5475|D-MPK2|D-P38a|D-p38|DMPK2|DmMPK2|Dp38|Erk2|P38|group 2|p38 alpha|p38A

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

95E5-95E5

Physical Location:

19976132-19977995 on NT_033777.2, complement

Gene Type:

protein-coding

Human Ortholog:

This gene has no human ortholog.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Mpk2
P Value:		4.78E-02
Note:		Acute up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	NAS
GO:0016909	SAP kinase activity	Molecular Function	TAS (10878576)
GO:0005524	ATP binding	Molecular Function	IEA
GO:0004707	MAP kinase activity	Molecular Function	NAS
GO:0004707	MAP kinase activity	Molecular Function	ISS (9417090)
GO:0004707	MAP kinase activity	Molecular Function	IGI (9417090)
GO:0004707	MAP kinase activity	Molecular Function	IDA (9584193)
GO:0004674	protein serine/threonine kinase activity	Molecular Function	NAS (10908587)
GO:0007165	signal transduction	Biological Process	NAS
GO:0008348	negative regulation of antimicrobial humoral response	Biological Process	IMP (9584193)
GO:0006970	response to osmotic stress	Biological Process	IDA (9417090)
GO:0006955	immune response	Biological Process	IDA (9584193)
GO:0006952	defense response	Biological Process	NAS
GO:0006950	response to stress	Biological Process	IMP (15514678)
GO:0006950	response to stress	Biological Process	IDA (9584193)
GO:0006468	protein amino acid phosphorylation	Biological Process	NAS (10908587)
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0000165	MAPKKK cascade	Biological Process	NAS (10878576)
GO:0000165	MAPKKK cascade	Biological Process	ISS (9417090)
GO:0000165	MAPKKK cascade	Biological Process	IDA (9584193)