ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CG12290

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

97A6-97A6

Physical Location:

22055973-22059069 on NT_033777.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 26696 Symbol (Name): OR2T1 (olfactory receptor, family 2, subfamily T, member 1)

Ortholog Status:

The human GeneID 26696 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_143213.2	NP_651470.1	NT_033777.2 range: 22055973..22059069

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	ISS (10908591)
GO:0001584	rhodopsin-like receptor activity	Molecular Function	IEA
GO:0004930	G-protein coupled receptor activity	Molecular Function	ISS (10908591)
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	IEA
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	ISS (10908591)