ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CG4849

Alias:

eEF2

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

98B6-98B6

Physical Location:

23789137-23792687 on NT_033777.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 9343 Symbol (Name): EFTUD2 (elongation factor Tu GTP binding domain containing 2)

Ortholog Status:

The human GeneID 9343 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		CG4849
P Value:		3.83E-02
Note:		Acute up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_143348.2	NP_651605.1	NT_033777.2 range: 23789137..23792687

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005682	snRNP U5	Cellular Component	ISS (10908584)
GO:0005829	cytosol	Cellular Component	ISS (10908586)
GO:0030532	small nuclear ribonucleoprotein complex	Cellular Component	ISS (10908584)
GO:0003746	translation elongation factor activity	Molecular Function	ISS (10908586)
GO:0003924	GTPase activity	Molecular Function	IEA
GO:0005525	GTP binding	Molecular Function	IEA
GO:0000398	nuclear mRNA splicing, via spliceosome	Biological Process	ISS (10908584)
GO:0006414	translational elongation	Biological Process	ISS (10908586)