ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

fkh

Alias:

CG10002|Dmfkh|Sebp2

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

98D5-98D5

Physical Location:

24407537-24410804 on NT_033777.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3170 Symbol (Name): FOXA2 (forkhead box A2)

Ortholog Status:

The human GeneID 3170 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		fkh
P Value:		4.01E-03
Note:		Slow up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_079818.2	NP_524542.1	NT_033777.2 range: 24407537..24410804, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	ISS
GO:0005634	nucleus	Cellular Component	NAS
GO:0043565	sequence-specific DNA binding	Molecular Function	IEA
GO:0030528	transcription regulator activity	Molecular Function	NAS
GO:0003700	transcription factor activity	Molecular Function	ISS
GO:0007435	salivary gland morphogenesis	Biological Process	IMP (10976053)
GO:0007435	salivary gland morphogenesis	Biological Process	TAS (11598957\|12742168)
GO:0007439	ectodermal gut development	Biological Process	TAS (10512197)
GO:0007443	Malpighian tubule morphogenesis	Biological Process	TAS (10512197)
GO:0007432	salivary gland boundary specification	Biological Process	NAS
GO:0007431	salivary gland development	Biological Process	NAS (14624839)
GO:0007431	salivary gland development	Biological Process	IMP (15901661)
GO:0006916	anti-apoptosis	Biological Process	TAS (12742168)
GO:0006916	anti-apoptosis	Biological Process	IMP (10976053)
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	NAS
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	ISS
GO:0001706	endoderm formation	Biological Process	TAS (11959838)
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	TAS (11598957)