ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Hrb98DE

Alias:

CG9983|E7Delta6|HDP(P9)|HRB98DE/hrp38|Hrb1|Pen9|anon-E7Delta6|hrp38|p9

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

98D6-98D6

Physical Location:

24425528-24431498 on NT_033777.2

Gene Type:

protein-coding

Human Ortholog:

This gene has no human ortholog.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hrb98DE
P Value:		1.26E-02
Note:		Acute down-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0030529	ribonucleoprotein complex	Cellular Component	IDA (1730753)
GO:0030529	ribonucleoprotein complex	Cellular Component	IPI (1730753)
GO:0030529	ribonucleoprotein complex	Cellular Component	ISS (1730753)
GO:0030529	ribonucleoprotein complex	Cellular Component	NAS
GO:0030530	heterogeneous nuclear ribonucleoprotein complex	Cellular Component	ISS
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0003676	nucleic acid binding	Molecular Function	IEA
GO:0003729	mRNA binding	Molecular Function	ISS (10908586)
GO:0003729	mRNA binding	Molecular Function	NAS