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Gene Information
Gene ID:43496
Organism:Drosophila melanogaster (Fly)
Genetic Location:99B8-99B8
Physical Location:25540260-25540673 on NT_033777.2
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Obp99d
P Value:1.66E-04
Note:Slow up-regulation
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_143455.1NP_651712.1NT_033777.2 range: 25540260..25540673
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005549odorant bindingMolecular FunctionIEA
GO:0006810transportBiological ProcessIEA
GO:0035071salivary gland cell autophagic cell deathBiological ProcessIEP (12593804)
GO:0048102autophagic cell deathBiological ProcessIEP (12593804)
Other Database Cross Links
NCBI Entrez Gene:43496