ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

pan

Alias:

CG17964|CG32005|CG34403|DTCF|Dmel_CG17964|Dmel_CG32005|IA5|LEF-1|LEF/TCF|LEF/TCF-1|Lef|TCF|TCF/LEF|TCF/LEF1|Tcf-1|cTCF|l(4)102ABb|l(4)13|lef1|unnamed

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

102A3-102A4

Physical Location:

89955-129429 on NC_004353.3

Gene Type:

protein-coding

Human Ortholog:

This gene has no human ortholog.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		pan
P Value:		1.32E-02
Note:		Slow up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005667	transcription factor complex	Cellular Component	ISS
GO:0003677	DNA binding	Molecular Function	IEA
GO:0016566	specific transcriptional repressor activity	Molecular Function	IMP (16828735)
GO:0035277	spiracle morphogenesis, open tracheal system	Biological Process	IMP (15930099)
GO:0030178	negative regulation of Wnt receptor signaling pathway	Biological Process	NAS (12147138)
GO:0030111	regulation of Wnt receptor signaling pathway	Biological Process	IMP (17267442)
GO:0016055	Wnt receptor signaling pathway	Biological Process	TAS (10973066)
GO:0016055	Wnt receptor signaling pathway	Biological Process	NAS
GO:0009880	embryonic pattern specification	Biological Process	IMP (12730381)
GO:0007507	heart development	Biological Process	TAS (10973066\|12027431)
GO:0007500	mesodermal cell fate determination	Biological Process	TAS (12027431)
GO:0007476	imaginal disc-derived wing morphogenesis	Biological Process	IMP (12730381)
GO:0007367	segment polarity determination	Biological Process	NAS
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	ISS
GO:0045610	regulation of hemocyte differentiation	Biological Process	IMP (15381778)