Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:43797
Organism:Drosophila melanogaster (Fly)
Genetic Location:102C2-102C2
Physical Location:578607-586561 on NC_004353.3
Gene Type:protein-coding
Human Ortholog:GeneID: 5814    Symbol (Name): PURB (purine-rich element binding protein B)
Ortholog Status:The human GeneID 5814 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Pur-alpha
P Value:1.44E-02
Note:Slow up-regulation, have human and mouse orthologs.
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_079885.1NP_524624.1NC_004353.3 range: 578607..586561
NM_166767.1NP_726579.1NC_004353.3 range: 578607..586561
NM_166768.1NP_726580.1NC_004353.3 range: 578607..586561
NM_166769.1NP_726581.1NC_004353.3 range: 578607..586561
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0003697single-stranded DNA bindingMolecular FunctionNAS
GO:0016563transcription activator activityMolecular FunctionISS
Other Database Cross Links
NCBI Entrez Gene:43797