ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

bgm

Alias:

2a9hom|BG:DS01514.2|BG:DS0514.2|CG4501|unnamed

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

34F1-34F1

Physical Location:

14013747-14019327 on NT_033779.4

Gene Type:

protein-coding

Human Ortholog:

GeneID: 81616 Symbol (Name): ACSBG2 (acyl-CoA synthetase bubblegum family member 2)

Ortholog Status:

The human GeneID 81616 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		bgm
P Value:		2.44E-02
Note:		Slow down-regulation, have human orthologs

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_079959.2	NP_524698.1	NT_033779.4 range: 14013747..14019327

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005575	cellular_component	Cellular Component	ND
GO:0004467	long-chain-fatty-acid-CoA ligase activity	Molecular Function	IMP (10373116)
GO:0004467	long-chain-fatty-acid-CoA ligase activity	Molecular Function	ISS (10471707)
GO:0001676	long-chain fatty acid metabolic process	Biological Process	IMP (10373116)
GO:0008152	metabolic process	Biological Process	IEA