ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Hmgs

Alias:

CG16796|CG4311|l(2)06214

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

53C1-53C1

Physical Location:

12223594-12228759 on NT_033778.3

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3157 Symbol (Name): HMGCS1 (3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble))

Ortholog Status:

The human GeneID 3157 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hmgs
P Value:		2.38E-03
Note:		Slow down-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0004421	hydroxymethylglutaryl-CoA synthase activity	Molecular Function	ISS
GO:0001700	embryonic development via the syncytial blastoderm	Biological Process	IMP (8978055)
GO:0008299	isoprenoid biosynthetic process	Biological Process	IEA