ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Xbp1

Alias:

138/3|CG9415|XBP-1|anon-EST:Liang-1.41|clone 1.41|l(2)k13803

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

57C3-57C4

Physical Location:

17031049-17033257 on NT_033778.3

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7494 Symbol (Name): XBP1 (X-box binding protein 1)

Ortholog Status:

The human GeneID 7494 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	ISS
GO:0003700	transcription factor activity	Molecular Function	ISS (10471706)
GO:0042803	protein homodimerization activity	Molecular Function	ISS (12176927)
GO:0043565	sequence-specific DNA binding	Molecular Function	IEA
GO:0046983	protein dimerization activity	Molecular Function	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0045449	regulation of transcription	Biological Process	ISS