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Gene Information
Gene ID:44226
Symbol:Xbp1
Alias:138/3|CG9415|XBP-1|anon-EST:Liang-1.41|clone 1.41|l(2)k13803
Organism:Drosophila melanogaster (Fly)
Chromosome:2R
Genetic Location:57C3-57C4
Physical Location:17031049-17033257 on NT_033778.3
Gene Type:protein-coding
Human Ortholog:GeneID: 7494    Symbol (Name): XBP1 (X-box binding protein 1)
Ortholog Status:The human GeneID 7494 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Xbp1
P Value:4.27E-02
Note:Slow up-regulation
Dataset Information
Name:17054780
Method:Microarray
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_079983.2NP_524722.2NT_033778.3 range: 17031049..17033257
NM_166427.2NP_726032.2NT_033778.3 range: 17031049..17033257
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentISS
GO:0003700transcription factor activityMolecular FunctionISS (10471706)
GO:0042803protein homodimerization activityMolecular FunctionISS (12176927)
GO:0043565sequence-specific DNA bindingMolecular FunctionIEA
GO:0046983protein dimerization activityMolecular FunctionIEA
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0045449regulation of transcriptionBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:44226
FLYBASE:FBgn0021872