ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

bab2

Alias:

BAB2|BTB-II|BtbII|CG13911|CG9102|bab|bab-II

Organism:

Drosophila melanogaster (Fly)

Chromosome:

3L

Genetic Location:

61F2-61F3

Physical Location:

1140448-1177273 on NT_037436.3, complement

Gene Type:

protein-coding

Human Ortholog:

This gene has no human ortholog.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		bab2
P Value:		1.12E-02
Note:		Slow down-regulation

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_079155.2	NP_523879.2	NT_037436.3 range: 1140448..1177273, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005701	polytene chromosome chromocenter	Cellular Component	IDA (12954775)
GO:0005700	polytene chromosome	Cellular Component	IDA (12954775)
GO:0005634	nucleus	Cellular Component	TAS (11973274)
GO:0005634	nucleus	Cellular Component	IEA
GO:0003677	DNA binding	Molecular Function	NAS
GO:0005515	protein binding	Molecular Function	IEA
GO:0003700	transcription factor activity	Molecular Function	TAS (12350340)
GO:0003700	transcription factor activity	Molecular Function	IEP (11973274)
GO:0008585	female gonad development	Biological Process	IMP (11973274)
GO:0008585	female gonad development	Biological Process	IGI (11973274)
GO:0007480	imaginal disc-derived leg morphogenesis	Biological Process	IMP (11973274)
GO:0007480	imaginal disc-derived leg morphogenesis	Biological Process	IGI (11973274)
GO:0007455	eye-antennal disc morphogenesis	Biological Process	ISS (11973274)
GO:0006350	transcription	Biological Process	IEP (11973274)
GO:0045449	regulation of transcription	Biological Process	TAS (12350340)

Other Database Cross Links

NCBI Entrez Gene:

FLYBASE: