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Gene Information
Gene ID:44254
Symbol:bab2
Alias:BAB2|BTB-II|BtbII|CG13911|CG9102|bab|bab-II
Organism:Drosophila melanogaster (Fly)
Chromosome:3L
Genetic Location:61F2-61F3
Physical Location:1140448-1177273 on NT_037436.3, complement
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:bab2
P Value:1.12E-02
Note:Slow down-regulation
Dataset Information
Name:17054780
Method:Microarray
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_079155.2NP_523879.2NT_037436.3 range: 1140448..1177273, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005701polytene chromosome chromocenterCellular ComponentIDA (12954775)
GO:0005700polytene chromosomeCellular ComponentIDA (12954775)
GO:0005634nucleusCellular ComponentTAS (11973274)
GO:0005634nucleusCellular ComponentIEA
GO:0003677DNA bindingMolecular FunctionNAS
GO:0005515protein bindingMolecular FunctionIEA
GO:0003700transcription factor activityMolecular FunctionTAS (12350340)
GO:0003700transcription factor activityMolecular FunctionIEP (11973274)
GO:0008585female gonad developmentBiological ProcessIMP (11973274)
GO:0008585female gonad developmentBiological ProcessIGI (11973274)
GO:0007480imaginal disc-derived leg morphogenesisBiological ProcessIMP (11973274)
GO:0007480imaginal disc-derived leg morphogenesisBiological ProcessIGI (11973274)
GO:0007455eye-antennal disc morphogenesisBiological ProcessISS (11973274)
GO:0006350transcriptionBiological ProcessIEP (11973274)
GO:0045449regulation of transcriptionBiological ProcessTAS (12350340)
Other Database Cross Links
NCBI Entrez Gene:44254
FLYBASE:FBgn0025525