ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

disp

Alias:

CG2019|Disp|anon-WO0146227.1

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

83C5-83C5

Physical Location:

1675415-1682032 on NT_033777.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 84976 Symbol (Name): DISP1 (dispatched homolog 1 (Drosophila))

Ortholog Status:

The human GeneID 84976 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		disp
P Value:		1.67E-02
Note:		Acute down-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_079995.2	NP_524734.2	NT_033777.2 range: 1675415..1682032, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	NAS (11111088\|11932020)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	ISS (10619433)
GO:0004601	peroxidase activity	Molecular Function	IEA
GO:0020037	heme binding	Molecular Function	IEA
GO:0006887	exocytosis	Biological Process	TAS (11932020)
GO:0006979	response to oxidative stress	Biological Process	IEA
GO:0007224	smoothened signaling pathway	Biological Process	IMP (10619433\|11748147)
GO:0007280	pole cell migration	Biological Process	IGI (16256738)