ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

lola

Alias:

BEST:LD03274|BTB-IV|BcDNA:LD17006|BcDNA:RH31485|BtbIV|CG12052|CG18376|CG18378|CG18379|CG18380|CG18381|CG30012|CG30013|CG30014|LD03274|NEST:bs06a08|bs06a08.y1|eyeful|l(2)00642|l(2)s3697|sw59

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

47A11-47A13

Physical Location:

6369711-6430766 on NT_033778.3, complement

Gene Type:

protein-coding

Human Ortholog:

This gene has no human ortholog.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		lola
P Value:		4.41E-02
Note:		Slow up-regulation

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001032229.1	NP_001027400.1	NT_033778.3 range: 6369711..6430766, complement
NM_080027.4	NP_524766.2	NT_033778.3 range: 6369711..6430766, complement
NM_170617.3	NP_724945.1	NT_033778.3 range: 6369711..6430766, complement
NM_170618.3	NP_724946.1	NT_033778.3 range: 6369711..6430766, complement
NM_170619.2	NP_724949.2	NT_033778.3 range: 6369711..6430766, complement
NM_170620.2	NP_724950.1	NT_033778.3 range: 6369711..6430766, complement
NM_170621.3	NP_724951.1	NT_033778.3 range: 6369711..6430766, complement
NM_170622.4	NP_724952.2	NT_033778.3 range: 6369711..6430766, complement
NM_170623.4	NP_724953.2	NT_033778.3 range: 6369711..6430766, complement
NM_176128.3	NP_788308.2	NT_033778.3 range: 6369711..6430766, complement
NM_176129.3	NP_788309.2	NT_033778.3 range: 6369711..6430766, complement
NM_176130.3	NP_788310.2	NT_033778.3 range: 6369711..6430766, complement
NM_176131.3	NP_788311.2	NT_033778.3 range: 6369711..6430766, complement
NM_176132.2	NP_788312.2	NT_033778.3 range: 6369711..6430766, complement
NM_176133.3	NP_788313.1	NT_033778.3 range: 6369711..6430766, complement
NM_176134.2	NP_788314.1	NT_033778.3 range: 6369711..6430766, complement
NM_176135.3	NP_788315.1	NT_033778.3 range: 6369711..6430766, complement
NM_176136.3	NP_788316.2	NT_033778.3 range: 6369711..6430766, complement
NM_176137.3	NP_788317.1	NT_033778.3 range: 6369711..6430766, complement
NM_176138.3	NP_788318.1	NT_033778.3 range: 6369711..6430766, complement
NM_176139.2	NP_788319.1	NT_033778.3 range: 6369711..6430766, complement
NM_176140.2	NP_788320.1	NT_033778.3 range: 6369711..6430766, complement
NM_206082.2	NP_995804.1	NT_033778.3 range: 6369711..6430766, complement
NM_206083.2	NP_995805.1	NT_033778.3 range: 6369711..6430766, complement
NM_206084.2	NP_995806.1	NT_033778.3 range: 6369711..6430766, complement
NM_206085.2	NP_995807.1	NT_033778.3 range: 6369711..6430766, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (8050351\|12538650)
GO:0009288	flagellin-based flagellum	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	NAS
GO:0016563	transcription activator activity	Molecular Function	ISS (8050351)
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (12538650)
GO:0005198	structural molecule activity	Molecular Function	IEA
GO:0003774	motor activity	Molecular Function	IEA
GO:0003704	specific RNA polymerase II transcription factor activity	Molecular Function	NAS
GO:0003704	specific RNA polymerase II transcription factor activity	Molecular Function	ISS (8050351)
GO:0003702	RNA polymerase II transcription factor activity	Molecular Function	NAS
GO:0003676	nucleic acid binding	Molecular Function	IEA
GO:0019730	antimicrobial humoral response	Biological Process	IMP (16163390)
GO:0016199	axon midline choice point recognition	Biological Process	IMP (11880341)
GO:0016199	axon midline choice point recognition	Biological Process	IGI (11880341)
GO:0001539	ciliary or flagellar motility	Biological Process	IEA
GO:0007411	axon guidance	Biological Process	NAS
GO:0007411	axon guidance	Biological Process	IMP (8050351\|11880341)
GO:0007411	axon guidance	Biological Process	IGI (16979619)
GO:0007409	axonogenesis	Biological Process	IMP (8050351)
GO:0006357	regulation of transcription from RNA polymerase II promoter	Biological Process	NAS
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	ISS (8050351)