ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

MST1

Full Name:

macrophage stimulating 1 (hepatocyte growth factor-like)

Alias:

D3F15S2|DNF15S2|HGFL|MSP|NF15S2

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

3p21

Physical Location:

49696390-49701098 on NC_000003.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 15235 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		U28054
Fold Change:		-3, -1.8
Note:		Differential Expression on the cDNA array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Gene Information

Original ID1:

U28054

Dataset Information

Name:		12065639
Method:		Microarray
Tissue:		Frontal and motor cortices
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Mayfield et al. J Neurochem. (2002) Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. PubMed
Summary:		We used cDNA microarrays to analyze expression of approximately 10 000 genes in the frontal and motor cortices of three groups of chronic alcoholic and matched control cases. Fluorescent intensity ratios of 1.4-fold or greater in either direction (representing the 99% confidence interval) were used to indicate differentially expressed genes.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_020998.2	NP_066278.2	NC_000003.10 range: 49696390..49701098, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0003824	catalytic activity	Molecular Function	IEA
GO:0004252	serine-type endopeptidase activity	Molecular Function	IEA
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0006508	proteolysis	Biological Process	IEA
GO:0007596	blood coagulation	Biological Process	IEA
GO:0008150	biological_process	Biological Process	ND