ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Hsp70Ab

Alias:

CG18743|DMHSP7A2|GRP78|HSP70|Hsp 70|Hsp70A|dhsp70|hs70|hsp-70|hsp70 87A|hsp70(87A)

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

87A3-87A3

Physical Location:

7784274-7786672 on NT_033777.2

Gene Type:

protein-coding

Human Ortholog:

This gene has no human ortholog.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hsp70Ab
P Value:		4.31E-02
Note:		Acute up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_080059.2	NP_524798.2	NT_033777.2 range: 7784274..7786672

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005524	ATP binding	Molecular Function	IEA
GO:0009408	response to heat	Biological Process	IMP (16204210)
GO:0009408	response to heat	Biological Process	ISS
GO:0009408	response to heat	Biological Process	NAS
GO:0035080	heat shock-mediated polytene chromosome puffing	Biological Process	IMP (16204210)