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Gene Information
Gene ID:45233
Alias:Acap|BcDNA:LD24380|CAP|CG33979|CG5061|CG5074|Dcap|acu|capping protein|cyclase-associated protein|l(2)06955
Organism:Drosophila melanogaster (Fly)
Genetic Location:21F1-21F1
Physical Location:1151677-1158263 on NT_033779.4, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 10487    Symbol (Name): CAP1 (CAP, adenylate cyclase-associated protein 1 (yeast))
Ortholog Status:The human GeneID 10487 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:capt
P Value:7.77E-04
Note:Slow up-regulation, have human and mouse orthologs.
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001038780.1NP_001033869.1NT_033779.4 range: 1151677..1158263, complement
NM_001038781.1NP_001033870.1NT_033779.4 range: 1151677..1158263, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0008179adenylate cyclase bindingMolecular FunctionISS (10471706)
GO:0003779actin bindingMolecular FunctionIEA
GO:0003779actin bindingMolecular FunctionISS (10985383)
GO:0048477oogenesisBiological ProcessIMP (10847682)
GO:0048190wing disc dorsal/ventral pattern formationBiological ProcessIMP (16049109)
GO:0008407bristle morphogenesisBiological ProcessIMP (10847682)
GO:0008360regulation of cell shapeBiological ProcessIMP (10847682)
GO:0000902cell morphogenesisBiological ProcessIMP (12975351)
GO:0008154actin polymerization and/or depolymerizationBiological ProcessIMP (10847682)
GO:0008103oocyte microtubule cytoskeleton polarizationBiological ProcessIMP (10985383)
GO:0007015actin filament organizationBiological ProcessIMP (10985383|11584269)
GO:0048749compound eye developmentBiological ProcessIMP (10847682)
Other Database Cross Links
NCBI Entrez Gene:45233