ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

capt

Alias:

Acap|BcDNA:LD24380|CAP|CG33979|CG5061|CG5074|Dcap|acu|capping protein|cyclase-associated protein|l(2)06955

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

21F1-21F1

Physical Location:

1151677-1158263 on NT_033779.4, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 10487 Symbol (Name): CAP1 (CAP, adenylate cyclase-associated protein 1 (yeast))

Ortholog Status:

The human GeneID 10487 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		capt
P Value:		7.77E-04
Note:		Slow up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0008179	adenylate cyclase binding	Molecular Function	ISS (10471706)
GO:0003779	actin binding	Molecular Function	IEA
GO:0003779	actin binding	Molecular Function	ISS (10985383)
GO:0048477	oogenesis	Biological Process	IMP (10847682)
GO:0048190	wing disc dorsal/ventral pattern formation	Biological Process	IMP (16049109)
GO:0008407	bristle morphogenesis	Biological Process	IMP (10847682)
GO:0008360	regulation of cell shape	Biological Process	IMP (10847682)
GO:0000902	cell morphogenesis	Biological Process	IMP (12975351)
GO:0008154	actin polymerization and/or depolymerization	Biological Process	IMP (10847682)
GO:0008103	oocyte microtubule cytoskeleton polarization	Biological Process	IMP (10985383)
GO:0007015	actin filament organization	Biological Process	IMP (10985383\|11584269)
GO:0048749	compound eye development	Biological Process	IMP (10847682)