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Gene Information
Gene ID:4524
Full Name:5,10-methylenetetrahydrofolate reductase (NADPH)
Organism:Homo sapiens (Human)
Genetic Location:1p36.3
Physical Location:11768373-11788701 on NC_000001.9, complement
Gene Type:protein-coding
Orthologs:This gene has Mouse: 17769 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:MTHFR
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Information
Original IDNo. of PublicationsPhenotype
MTHFR3Alcohol-Induced Disorders
MTHFR1Alcohol-Induced Disorders Nervous System
MTHFR5Alcohol-Related Disorders
MTHFR1Alcohol Withdrawal Seizures
HuGE Navigator Dataset
Name:HuGE Navigator
Method:Literature data mining
Publication:Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_005957.3NP_005948.3NC_000001.9 range: 11768373..11788701, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005829cytosolCellular ComponentEXP (7726158)
GO:0004489methylenetetrahydrofolate reductase (NADPH) activityMolecular FunctionEXP (7726158)
GO:0004489methylenetetrahydrofolate reductase (NADPH) activityMolecular FunctionIEA
GO:0004489methylenetetrahydrofolate reductase (NADPH) activityMolecular FunctionTAS (7647779)
GO:0005515protein bindingMolecular FunctionIPI (15231747)
GO:0016491oxidoreductase activityMolecular FunctionIEA
GO:0006520amino acid metabolic processBiological ProcessTAS (7647779)
GO:0006555methionine metabolic processBiological ProcessIEA
GO:0008015blood circulationBiological ProcessTAS (7647779)
Other Database Cross Links
NCBI Entrez Gene:4524
HuGE Navigator:4524