ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

RpL12

Alias:

CG3195|L12|anon-EST:Posey236

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

60B7-60B7

Physical Location:

19947922-19949038 on NT_033778.3

Gene Type:

protein-coding

Human Ortholog:

GeneID: 6136 Symbol (Name): RPL12 (ribosomal protein L12)

Ortholog Status:

The human GeneID 6136 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005811	lipid particle	Cellular Component	IDA (16979555)
GO:0022625	cytosolic large ribosomal subunit	Cellular Component	ISS
GO:0003735	structural constituent of ribosome	Molecular Function	ISS
GO:0000022	mitotic spindle elongation	Biological Process	IMP (17412918)
GO:0006412	translation	Biological Process	ISS