ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pdp1

Alias:

CG17888|PDP11epsilon|Pdp1epsilon|anon-WO0140519.206

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

66A14-66A17

Physical Location:

7807434-7860471 on NT_037436.3, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3131 Symbol (Name): HLF (hepatic leukemia factor)

Ortholog Status:

The human GeneID 3131 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Pdp1
P Value:		2.44E-02
Note:		Slow up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (10926776)
GO:0003677	DNA binding	Molecular Function	IPI (10926776)
GO:0043565	sequence-specific DNA binding	Molecular Function	IEA
GO:0042803	protein homodimerization activity	Molecular Function	ISS (12176927)
GO:0046983	protein dimerization activity	Molecular Function	IEA
GO:0003700	transcription factor activity	Molecular Function	IEA
GO:0003700	transcription factor activity	Molecular Function	TAS (10926776)
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0042023	DNA endoreduplication	Biological Process	IMP (16313897)
GO:0040007	growth	Biological Process	IMP (16313897)
GO:0007623	circadian rhythm	Biological Process	TAS (15312644)
GO:0007623	circadian rhythm	Biological Process	IMP (12581523)
GO:0007623	circadian rhythm	Biological Process	IGI (12581523)
GO:0006350	transcription	Biological Process	TAS (10926776)
GO:0007584	response to nutrient	Biological Process	IMP (16313897)
GO:0007067	mitosis	Biological Process	IMP (16313897)
GO:0007623	circadian rhythm	Biological Process	IDA (12581523)